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HRH2 gene: Histamine receptor 2 is active in the production of stomach acid, the sinus node of the heart, and other places in the body

More recently, a bi-specific antibody, trontinemab, against TfR and A has been tested in non-human primates 94 and AD patients (NCT04023994)

Defects in both UPR signaling and ERAD have been strongly implicated in neurodegenerative diseases, including Alzheimers disease and amyotrophic lateral sclerosis (ALS), highlighting the clinical relevance of maintaining proper ER zinc homeostasis 126,127,128